Cooperation between wet granulator and other powder processing equipment
As a commonly used equipment in the pharmaceutical, food and other industries, wet granulator usually does not work alone, but cooperates with other powder processing equipment to form a complete production line to achieve a series of processes such as material mixing, granulation, and drying.
Cooperation relationship between wet granulator and other equipment
Mixer: Before wet granulation, the main drug, auxiliary materials and adhesives usually need to be fully mixed in the mixer to ensure the uniformity of the materials.
Wet granulator: Add the mixed materials to the wet granulator, add the binder by spraying or other means to form granules.
Dryer: The wet granules after granulation need to be dried to reduce the moisture content and improve the stability of the granules. The dryer can be a fluidized bed dryer, spray dryer, etc.
Sieving machine: The dried granules need to be sieved to obtain granules with uniform particle size and remove oversized or undersized particles.
Coating machine: If necessary, the granules can be coated to improve their appearance, taste or release characteristics.
Issues that need to be noted during the matching process
Equipment matching: The performance parameters, interface sizes, etc. of different types of wet granulators, mixers, dryers and other equipment need to be matched to ensure the smooth operation of the production line.
Optimization of process parameters: The granulation process parameters of different materials are different, and they need to be optimized according to the properties of the materials to obtain the best granulation effect.
Material transportation: During the transportation of materials between different equipment, it is necessary to ensure that the materials are not separated or confused.
Cleaning and maintenance: Cleaning and maintenance of equipment are the key to ensuring production quality and extending the service life of equipment.
Common wet granulation production lines
High shear wet granulation production line: It is composed of a mixer, a high shear wet granulator, a fluidized bed dryer, a sieving machine, etc., and is suitable for preparing granules with uniform particle size and good fluidity.
Fluidized bed wet granulation production line: It is composed of a mixer, a fluidized bed wet granulator, a fluidized bed dryer, etc., and is suitable for preparing large batches of granules with a wide particle size distribution.
Rotary disc wet granulation production line: It consists of a mixer, a rotary disc wet granulator, a dryer, etc. It is suitable for preparing large or irregular shaped particles.
Automation of wet granulation production line
With the continuous development of automation technology, wet granulation production lines have gradually realized automated control, improving production efficiency and product quality. Through automation systems such as PLC and DCS, real-time monitoring and control of the entire production process can be achieved, such as material addition, temperature control, humidity adjustment, etc.