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Dry Granulator Manufacturers

Dry granulation is a sophisticated process utilized in various industrial sectors, particularly pharmaceuticals and chemicals, to transform fine powder materials into granules. At the heart of this operation is the dry granulator, a pivotal piece of equipment renowned for its efficiency and precision in granule production.
This innovative technology bypasses the traditional wet granulation method, reducing moisture content and avoiding the need for drying processes. The dry granulator operates by compacting powder materials between two counter-rotating rollers, applying immense pressure to form dense, uniform granules of controlled size and shape.
One of the primary advantages of dry granulation is its ability to handle heat-sensitive or moisture-sensitive materials without compromising their integrity. This makes it ideal for processing sensitive pharmaceutical compounds or chemical substances that require precise handling to maintain efficacy and stability.
Furthermore, the dry granulator is designed with advanced automation features, ensuring consistent granule quality and minimizing human intervention. Its versatility allows for seamless integration into existing production lines, enhancing overall efficiency and reducing operational costs.

Who Are We?

Changzhou Yimin Drying Equipment Co., Ltd. is China Dry Granulator Manufacturers and Dry Granulator factory, located in the birthplace of China's drying equipment industry - Jiaoxi Industrial Park, Zhenglu Town, Changzhou City. It is adjacent to the Beijing-Shanghai Expressway, Shanghai-Nanjing Railway, and 5 kilometers from the Hengshan Crossing of the Shanghai-Nanjing Expressway. It is a key backbone enterprise in China's drying industry and pharmaceutical machinery. The company currently covers an area of ​​33,000 square meters and a building area of ​​18,000 square meters. The company has modern large-scale production workshops and equipment, fixed assets of more than 80 million yuan, and more than 120 employees. The founder of the company, Mr. Fan Yiming, has been committed to the research, production and operation of drying equipment for more than 20 years. At the same time, he has also brought together a group of high-quality talents integrating scientific research, design, production and service, and has long-term horizontal cooperation with relevant colleges and universities to continuously update and develop products.

At present, the company has more than 180 sets of processing equipment and strong technical force. It produces more than 2,000 sets of various drying, mixing, granulating, crushing, dust removal, powder screening and other equipment annually. The products have developed into eight series with more than 300 specifications and varieties, which are widely used in pharmaceutical, chemical, food, feed, mining, agricultural and sideline products, electronics, light industry and other industries. The products are distributed throughout the country and exported to the United States, Japan, Russia, Hong Kong, Taiwan and other places.

The factory also has a large test workshop with a full range of prototypes. Customers are welcome to bring materials for testing and ordering.

Changzhou Yimin Drying Equipment Co., Ltd.

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Specific application of dry granulation technology in the pharmaceutical industry

Dry granulation technology, as a solvent-free granulation method, is widely used in the pharmaceutical industry. Compared with wet granulation, dry granulation has the following advantages:

Avoid solvent residue: Since no solvent is used, the influence of solvent residue on product quality can be avoided, which is particularly suitable for drugs that are sensitive to solvents.

Easy to operate: The process flow is relatively simple and easy to operate.

Low energy consumption: No drying process is required, and energy consumption is low.

Applicable to heat-sensitive materials: Avoids the damage of heat-sensitive materials by high temperature.

Specific application scenarios of dry granulation technology in the pharmaceutical industry
Direct tableting:
High particle strength: The particles obtained by dry granulation have high strength and can be directly used for tableting without adding adhesives.

Applicable to difficult-to-compress materials: It can improve the fluidity and tableting performance of difficult-to-compress materials.

Improve tablet quality: The tablets obtained have fast disintegration time and high bioavailability.

Pre-treatment for coating:
Improve the fluidity of particles: Dry granulation can improve the fluidity of particles and facilitate the subsequent coating process.
Improve the coating effect: The coating layer and the core particles are more firmly bonded.
Preparing sustained-release preparations:
Controlling drug release: By adjusting the process parameters, the release rate of the drug can be controlled to prepare sustained-release preparations.

Types and characteristics of dry granulation technology
Roller granulation: The material is pressed into sheets or strips by applying pressure with a roller, and then broken into particles. It is suitable for materials with larger particle sizes, and the prepared particles have high strength.
Extrusion granulation: The material is extruded through the die hole to form strips or filaments, and then broken into particles. It is suitable for materials with good plasticity, and the prepared particles have regular shapes.
Fluidized bed granulation: The material is collided and rubbed on the fluidized bed to make the particles gradually grow. It is suitable for materials with smaller particle sizes, and the prepared particles have uniform particle size distribution.

Challenges and solutions of dry granulation technology in the pharmaceutical industry
Dust problem: A large amount of dust will be generated during the dry granulation process, and it is necessary to strengthen the sealing and dust removal measures.
Insufficient particle strength: The particle strength of some materials is not enough, and it is necessary to add additives or optimize process parameters.
Equipment wear: Long-term operation of the equipment will cause wear and tear, and regular maintenance and replacement of wearing parts are required.